Addicted to Autophagy: Ph+ B-ALL May Acquire Imatinib-resistance and Enhanced Malignancy through a Highly-active Autophagy Pathway
abstract: The majority of chronic myeloid leukemia (CML) and some of acute lymphocytic leukemia (ALL) cases are associated with possessing the BCR-Abl fusion protein from an oncogenic translocation, resulting in a constantly active form of Abl and rapid proliferation. CML and ALL cells that possess...
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| Format: | Dissertation |
| Language: | English |
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2011
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| Online Access: | http://hdl.handle.net/2286/R.I.9272 |