The generation of a herpes simplex virus vector to target motor neurons

Herpes simplex virus (HSV) is a neurovirulent virus that in the course of natural infection of man predominantly infects sensory neurons. The aim of this project was to develop a safe, nonvirulent HSV, capable of expressing exogenous genes which altered the binding characteristics of the virus so th...

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Bibliographic Details
Main Author: Friel, Ruairi Donal
Published: University of Glasgow 2001
Subjects:
616
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250056