Transcriptional targeting of lentiviral vectors to the erythroblastic progeny of hematopoietic stem cells

Correction of blood genetic disorders requires permanent gene transfer into self renewing, hematopoietic stem cells (HSC), and regulation of transgene expression in specific cell lineages. HIV-derived lentiviral vectors are very effective in transducing rare, non-dividing stem cell populations witho...

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Bibliographic Details
Main Author: Lotti, Francesco
Published: Open University 2003
Subjects:
616
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275107