Macrocyclic nitrogen mustard prodrugs as hypoxia selective anti-cancer agents
The low selectivity of chemotherapy is an ongoing problem in the treatment of cancer. Prodrugs that are activated in vivo provide a therapeutic advantage for selective cytotoxicity. Here we have designed redox-active compounds that are electrochemically reduced in hypoxic (poorly oxygenated) tissue,...
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University of Glasgow
2003
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275627 |