The design and synthesis of inhibitors of the enzyme poly (adenosine diphosphate ribose) polymerase and the investigation of the mechanism of action of the suspected ultimate carcinogen chloroacetaldehyde
This thesis describes the preparation of inhibitors of the enzyme poly(adenosine diphosphate ribose)polymerase (PARP) and the mechanism of action of the carcinogen vinyl chloride. Initially the enzyme's function, purification and its known inhibitors are discussed. The enzyme's cofactor, n...
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University of Newcastle Upon Tyne
1995
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294376 |