Design of potential antiprotozoal daunorubicin derivatives

Daunorubicin is an antitumour antibiotic which is highly active against the sleeping sickness parasite Trypanosoma rhodesiense in vitro, but which lacks in vivo activity. The object of this work was to modify daunorubicin so as to promote in vivo activity, and to study the mechanism by which daunoru...

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Bibliographic Details
Main Author: Hardman, Mark Alan
Published: De Montfort University 1985
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356451