Phenotypic consequences of mutations in homologous recombination repair genes in colorectal cancer cells
The DNA damage response is important for maintaining genomic integrity following introduction of double-strand breaks (DSB) since illegitimate or incorrect repair of a DSB could promote malignant transformation. Mismatch-repair (MMR) deficient tumour cell lines are acutely sensitive to thymidine tre...
| Main Author: | |
|---|---|
| Published: |
University of Sheffield
2003
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397493 |