Phenotypic consequences of mutations in homologous recombination repair genes in colorectal cancer cells
The DNA damage response is important for maintaining genomic integrity following introduction of double-strand breaks (DSB) since illegitimate or incorrect repair of a DSB could promote malignant transformation. Mismatch-repair (MMR) deficient tumour cell lines are acutely sensitive to thymidine tre...
Main Author: | Scorah, Jennifer Susan |
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Published: |
University of Sheffield
2003
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Subjects: | |
Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397493 |
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