The role of PARP-1 in the cellular response to topoisomerase I poisons
P ARP-l inhibitors enhance DNA topoisomerase I (Topo I) poison-induced cytotoxicity and anti-tumour activity in vitro and in vivo but the underlying mechanism has not been defined. Two hypotheses have been proposed to explain this a) PARP-I modulates topo I activity via poly(ADP-ribosylation), or b)...
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University of Newcastle Upon Tyne
2004
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405346 |