An investigation of the importance of somatic mutations and basic residues in the binding of antiphospholipid antibodies to cardiolipin
Sequence analysis of human antiphospholipid antibodies (aPL) has shown that their binding properties are derived from the accumulation of replacement mutations and basic residues in their complementarity determining regions (CDRs). This thesis describes the effects of particular CDR motifs, often si...
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University College London (University of London)
2005
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414450 |