The Saccharomyces cerevisiae SNM1 gene and repair of anticancer drug-induced DNA interstrand cross-links

Saccharomyces cerevisiae (budding yeast) cells defective for the PSO2/SNM1 gene are uniquely sensitive to agents that produce DNA interstrand cross-links (ICLs), but not other forms of DNA damage. In the absence of Pso2, repair is stalled after the initial incision of ICLs, resulting in an accumulat...

Full description

Bibliographic Details
Main Author: Barber, Louise Jane
Published: University College London (University of London) 2004
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415564