Exploring agonist dependency of receptor-G protein-coupling and constitutive activity at muscarinic acetylcholine receptors
The effects of structurally diverse agonists were assessed on receptor-mediated activation of G-proteins using in Chinese hamster ovary cells stably expressing similar densities of M1 and M3 mACh receptors. Using a total [35S]-GTPgammaS binding protocol both receptor subtypes were shown to couple to...
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University of Leicester
2004
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416323 |