Analysis of mutations in alpha-synuclein and the protective effect of heat shock proteins in a model of alpha-synuclein-induced toxicity
Genetic studies have revealed three mutations (A30P, A53T and E46K) in alpha-synuclein (alpha-Syn) that cause Parkinson's disease (PD) in a small number of pedigrees with autosomal dominant inheritance. For the purpose of this thesis an in vitro model has been developed by stably over-expressin...
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University College London (University of London)
2005
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417032 |