Characterization of RNA aptamers that bind to HIV-1 gp120

RNA aptamers with 2'-fluoro-pyrimidine chemistry were previously selected by in vitro evolution to bind to monomeric HIV-1 gp120 from the R5 strain BaL. A group of 36 novel aptamers were cloned and sequenced from the heterogeneous pool and were tested for their ability to bind to gp120. The div...

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Bibliographic Details
Main Author: Cohen, Carla J.
Other Authors: James, William S.
Published: University of Oxford 2006
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437042