Regulation of the expression and function of P-glycoprotein by the nuclear xenobiotic receptor PXR
The intestinal expression of P-glycoprotein (Pgp) has recently been recognised to impact on the disposition of a wide range of orally administered drug compounds. From an evolutionary perspective, efflux transporters such as P-glycoprotein may have developed to protect the body from ingested toxins,...
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University of Newcastle upon Tyne
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485570 |