Use of in vitro metabolism models for in vivo drug metabolic clearance prediction
Recently human liver microsomes have been found to underpredict in vivo human intrinsic clearance (CLint); this has led to an increase in the use of fresh and cryopreserved human hepatocytes as an alternative in vitro system for the prediction of in vivo human CLint. The aim of the work in this thes...
| Main Author: | |
|---|---|
| Published: |
University of Manchester
2007
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487998 |