The role of hypoxia and its interaction with the PI3K/Akt pathway in the pathogenesis of malignant pleural mesothelioma
Carbonic Anhydrase (CA) IX, a surrogate marker of hypoxia, is upregulated downstream of the stabilisation of hypoxia-inducible factor (HIF)-1alpha and is over-expressed in solid tumours. Protein Kinase B, or Akt, known to have important intracellular roles including resistance to apoptosis, is activ...
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University of Leicester
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490859 |