MAPK regulation of DC IL-12 family is exploited by melanoma to subvert Th-1 priming
Effective anti-cancer responses are mediated by an IFN-y and Twi type immune profile. Crucial to the induction of IFN-y are the cytokines Il-27 and Il-12. Il-27 initiates Twi differentiation from naive T-cells and Il-12 quickly takes over to drive IFN-y and expand the TH-i population. Dendritic cell...
| Main Author: | |
|---|---|
| Published: |
University of Nottingham
2008
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490963 |