Role of mitogen-activated protein kinases in the synergenic induction of matrix metalloproteinase-1 and - 13 following Interleukin-1- and Onconstatin M stimulation
One of the major characteristics of both rheumatoid and osteoarthritis is aberrant matrix metalioproteinase (MMP) -1 and -13 induction leading to irreversible cartilage breakdown. MMP-1 and 13 induction is known to be mediated by interleukin -1 (IL-1) within the arthritic joint, furthermore it is al...
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University of Newcastle Upon Tyne
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492108 |