Role of mitogen-activated protein kinases in the synergenic induction of matrix metalloproteinase-1 and - 13 following Interleukin-1- and Onconstatin M stimulation
One of the major characteristics of both rheumatoid and osteoarthritis is aberrant matrix metalioproteinase (MMP) -1 and -13 induction leading to irreversible cartilage breakdown. MMP-1 and 13 induction is known to be mediated by interleukin -1 (IL-1) within the arthritic joint, furthermore it is al...
Main Author: | |
---|---|
Published: |
University of Newcastle Upon Tyne
2008
|
Subjects: | |
Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492108 |
Summary: | One of the major characteristics of both rheumatoid and osteoarthritis is aberrant matrix metalioproteinase (MMP) -1 and -13 induction leading to irreversible cartilage breakdown. MMP-1 and 13 induction is known to be mediated by interleukin -1 (IL-1) within the arthritic joint, furthermore it is also known that oncostatin M (OSM) potentiates the effects of IL-1 in a synergistic manner. Although the phenomenon of synergy with IL-1+0SM is well documented, little data exist explaining the precise underlying mechanism. |
---|