Pharmacogentic factors influencing the metabolism of 13-cis retinoic acid
5203 L $$aThe administration of 13-cis retinoic acid (13cisRA) improves 3-year event free survival rates in children with high-risk neuroblastoma. However, more than half of patients suffer relapse within 3 years. A high degree of variability in UcisRA pharmacokinetics has been reported, suggesting...
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University of Newcastle upon Tyne
2008
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Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493211 |
Summary: | 5203 L $$aThe administration of 13-cis retinoic acid (13cisRA) improves 3-year event free survival rates in children with high-risk neuroblastoma. However, more than half of patients suffer relapse within 3 years. A high degree of variability in UcisRA pharmacokinetics has been reported, suggesting that individualisation of dosing may further improve therapy. Several cytochrome P450 (CYP) and UDPglucuronosyltransferase (UGT) enzymes play a role in the metabolism of retinoic icid. Thus, genetic variation in CYP and UGT activity could underlie the individual differences in 13c/5RA metabolism and bioavailability. |
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