Prediction of metabolic clearance by glucuronidation using in vitro systems
In drug development, ADME issues are still large contributors to drug attrition. The use of in vitro systems, such as microsomes and hepatocytes, for the assessment of metabolic stability and prediction of in vivo clearance, are well established for substrates of the cytochrome P450 enzymes (CYPs)....
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University of Manchester
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493442 |