An In Vitro Approach to Assess Intestinal Drug Metabolism and Transport
The epithelium of the small intestine provides a physical and biochemical banner that restricts the transcellular absorption of orally dosed drugs into the bloodstream through mechanisms including P-glycoprotein (Pgp) and Cytochrome P450 3A4 (CYP3A4). P-glycoprotein is constitutively expressed on th...
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University of Manchester
2007
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Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493464 |