An In Vitro Approach to Assess Intestinal Drug Metabolism and Transport
The epithelium of the small intestine provides a physical and biochemical banner that restricts the transcellular absorption of orally dosed drugs into the bloodstream through mechanisms including P-glycoprotein (Pgp) and Cytochrome P450 3A4 (CYP3A4). P-glycoprotein is constitutively expressed on th...
| Main Author: | |
|---|---|
| Published: |
University of Manchester
2007
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493464 |