The role of GFAP mutation in Alexander disease
Alexaneder disease (AxD) is a primary genetic disorder of astrocyte caused by mutations in the type 111 intermediate filament (IF) glial fibrillary acidic protein (GFAP). The pathological hallmark of this disease is the presence of Rosenthal fibres (RF), ubiquitinated protein aggregates with GFAP be...
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Durham University
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495839 |