Donor engineered dendritic cells to generate tolerogenic regulatory T cells for renal transplantation
Immature dendritic cells (DCs) can be instrumental in the induction of peripheral tolerance promoting the generation of regulatory T cells. Since NF-kB is central to DC maturation, rat bone marrow-derived DCs were transfected with an adenoviral vector encoding for a kinase-defective dominant negativ...
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Open University
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497388 |