Synthesis and biochemical evaluation of novel non-steroidal inhibitors of the cytochrome P450 enzyme 17α-hydroxylase/17,20-lyase in the treatment of hormone-dependent prostate cancer
A high proportion of prostate cancers have been shown to be androgen-dependent. The biosynthesis of the androgens is catalysed by the cytochrome P450 enzyme 17[alpha]-hydroxylase/17, 20-lyase (P450[sub]17[alpha]), which is responsible for the conversion of C[sub]21 steroids (for example pregnenolone...
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Kingston University
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497588 |