Inhibition of myostatin (GDF-8) via myostatin propeptide minigenes : a potential gene therapy for Duchenne muscular dystrophy
The objective of this project was to evaluate the alleviation of muscle wasting phenotypes by hepatic delivery and expression of a recombinant mutated myostatin propeptide mini gene in wild type mice. Initial work focused on using naked plasmid DNA as a vector for delivery of the therapeutic gene. V...
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Royal Holloway, University of London
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497826 |