Computational study of dually phosphorylated peptides binding to the SRC SHZ domain
The binding of tyrosine phosphorylated targets by SH2 domains is required for the propagation of many cellular signals in higher eukaryotes. In this thesis we studied computationally the bindings of Src SH2 domain to Ac-PQpYEpYIPI-NH2 and Ac- PQpYIpYVPI-NH2, two dually-phosphorylated ligands, and th...
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Birkbeck (University of London)
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498770 |