A structure-function analysis of the final stages of novobiocin biosynthesis
The aminocoumarin antibiotics are of interest as they Inhibit proven antibacterial targets such as DNA gyrase. The novlosyl moiety and its decorations are very important for antibiotic activity. NovP and NovN are the two enzymes that catalyze attachment of these functional groups in the case of novo...
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University of East Anglia
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502229 |