Molecular analysis of claspin function in vertebrate cells

Claspin is a large, acidic, DNA binding protein required for the ATR mediated activation of Chk1 in response to DNA replication stress. Upon checkpoint activation Claspin is phosphorylated which allows binding to Chk1. This binding in turn promotes the phosphorylation and activation of Chk1 by ATR....

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Bibliographic Details
Main Author: Larkin, Conor
Published: University of Glasgow 2010
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Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512092