Analysis of association studies and inference of haplotypic phase using hidden Markov models
In this thesis I focus on the development and application of hidden Markov model (HMM) to solve problems in statistical genetics. Our method, based on a HMM, models the joint haplotype structure in the samples, where the parameters in the model are estimated by the Baum-Welch EM algorithm. Also, the...
| Main Author: | |
|---|---|
| Other Authors: | |
| Published: |
Imperial College London
2009
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.513494 |