Characterisation of ADAMTS-4 endocytosis by chondrosarcoma cells and chondrocytes

Aggrecan is one of the most abundant components of the articular cartilage matrix and its degradation by aggrecanases is considered to be a key early event in the development of osteoarthritis. This study investigates whether the extracellular level of ADAMTS-4 (a disintegrin and metalloproteinase w...

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Bibliographic Details
Main Author: Owen, Kathryn
Other Authors: Nagase, Hideaki
Published: Imperial College London 2009
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.513536