Studies of the structure of cytochrome P450 4A1

Cytochrome P450 4A1 (CYP4A1) is involved in omega-hydroxylation of fatty acids and eicosanoids. The resulting metabolites may have physiological activities such as regulation of blood pressure. In order to identify structural determinants of substrate binding, site-directed mutagenesis was used. Acc...

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Bibliographic Details
Main Author: Fan, Ming Qi
Published: University of Nottingham 2002
Subjects:
572
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514668