Convergence of cytokines and hypoxia on colorectal cancer angiogenesis
Over-expression of Epidermal Growth Factor (EGF) and hypoxia are features of colorectal cancer (CRC). Such observations have helped develop novel therapies such as cetuximab, a recombinant monoclonal EGF receptor antibody antagonist. Recent studies uncovered a pro-angiogenic role for EGF but it is u...
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Imperial College London
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518969 |