Pharmacological therapies for monogenic obesity caused by MC4R dysfunction
Mutations in the melanocortin-4 receptor (MC4R) are the most common cause of monogenic obesity. The majority of MC4R mutations are predicted to cause the receptor to aberrantly fold. Misfolded MC4R fails to traffic to the plasma membrane (PM) and is retained in the endoplasmic reticulum (ER). Recent...
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Queen Mary, University of London
2010
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529000 |