Inhibition of HCV replication by host cell innate antiviral defences
RIG-I and MDA5 are the major intracellular sensors for the induction of IFN-β, by dsRNA, in Huh7 cells. It was found that the expression of RIG-I, MDA5 and the signalling mediators TRIF, MAVS and MyD88 were upregulated in Huh7 HCV RNA replicon cells. Similar findings were obtained in Huh7 cells infe...
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Imperial College London
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532062 |