Nicastrin and the gamma-secretase complex in breast cancer
γ‐secretase is a membrane‐bound proteolytic complex, formed by nicastrin, APH1, presenilin and pen‐2, which cleaves over sixty known substrates, including Notch and Ecadherin, thus regulating cellular processes such as proliferation and adhesion. High levels of nicastrin have been demonstrated in 47...
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Imperial College London
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535983 |