The structure, conformation and mechanism of the bacterial toxin pneumolysin from Streptococcus pneumoniae

Pneumolysin is a virulence factor produced by the human pathogen Streptococcus pneumoniae. It acts in disease to damage cell membranes via pore formation and to activate the complement system directly. Pore formation is accompanied by the transition of the protein from an aqueous, monomeric conforma...

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Bibliographic Details
Main Author: Gilbert, Robert John Crispin
Other Authors: Andrew, Peter
Published: University of Leicester 1998
Subjects:
579
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536640