A novel, versatile D-BCD steroid construction strategy, illustrated by the total syntheses of estrone and desogestrel
Proposed are the total syntheses of the steroids desogestrel and estrone, utilizing a 1,4 addition/alkylation process to install the correct stereochemistry at C8, C13 and C14 in a single-pot operation. The racemic total synthesis of desogestrel includes a successful domino anionic cyclisation leadi...
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University of Southampton
2010
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538993 |