Synthesis and evaluation of novel PI3-K-Akt-mTOR modulators
The phosphoinositide 3-kinase / Akt / mammalian target of rapamycin (PI3-K-AktmTOR) signalling pathway is a regulator of critical cellular functions including apoptosis, metabolism and survival. Its deregulation is involved in numerous human diseases. This thesis describes the synthesis and biologic...
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Imperial College London
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540661 |