The role of ER stress and the unfolded protein response in obesity associated type 2 diabetes
Pancreatic β-cell dysfunction plays a central role in the pathogenesis of type 2 diabetes. This dysfunction is characterised by secretory defects in the β-cells and the loss of β-cell mass, at least in part secondary to increased β-cell apoptosis. Although the mechanisms through which β-cell dysfunc...
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University of Leicester
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548396 |