High glucose and human endothelial cell ageing
Increased generation of reactive oxygen species (ROS) in hyperglycaemia is linked to endothelial cell DNA damage in diabetes. Nuclear and/or mitochondrial DNA (mtDNA) damage may accelerate ageing of endothelial cells and, in part, account for the endothelial dysfunction associated with the pathogene...
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University of Leicester
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548460 |