Synthesis of agents potentially useful in cancer chemotherapy
A range of novel, potent, inhibitors of NAD(P)H quinone oxidoreductase 1 (NQO1) and NAD(P)H quinone oxidoreductase 2 (NQO2) were synthesised. The therapeutic utility of this could be three-fold: 1) Impairing tumour growth.2) Promoting the transient degradation of the p53 tumour suppressor protein in...
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University of Manchester
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549643 |