Cytochrome P450 profiles in rat and their prediction from UPLC-MS metabolic profiles

Cytochrome P450 enzymes (CYPs) are of great interest to pharmaceutical industry due to their major role in drug metabolism and drug-drug interactions in man. As CYPs also act on endogenous substrates and are regulated by nuclear receptors involved in biochemical pathways, their profiles are likely t...

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Bibliographic Details
Main Author: Masson, Perrine Anne Sophie
Other Authors: Want, Elizabeth ; Nicholson, Jeremy
Published: Imperial College London 2012
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550941