Crystallographic and biophysical studies of telomeric RNA and DNA G-quadruplex-drug complexes
The terminal regions of eukaryotic chromosomes - the telomeres - play a crucial role maintaining genomic integrity and in the regulation of cellular senescence and apoptosis. These regions - composed of a complex array of proteins and nucleic acid structures - are found to be dysregulated in a high...
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University of London
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550982 |