Genetic determinants of Helicobacter pylori vacuolating cytotoxin activity

Helicobacter pylori infection is the main cause of peptic ulcer disease, and a significant risk factor for gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma. A major virulence determinant is the vacuolating cytotoxin VacA, which causes cytoplasmic vacuolation, and other e...

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Bibliographic Details
Main Author: Letley, Darren Peter
Published: University of Nottingham 2011
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555341