Differential responsiveness of tumour necrosis factor receptors (TNFR) type 1 and 2 : the critical role of the TNFR stalk region
The pro-inflammatory cytokine tumour necrosis factor (TNF) exerts its bioactivity via two plasma membrane receptors, TNF receptor (TNFR)1 and TNFR2. Both receptors are fully activated by membrane-bound TNF, while soluble TNF (sTNF) activates only TNFR1 efficiently. Preliminary data from our group su...
| Main Author: | |
|---|---|
| Published: |
University of Newcastle Upon Tyne
2011
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555992 |