Investigating the role of Pellino1, an E3 ubiquitin ligase, in modulating the signalling pathways that control the inflammatory response
Pellino1 was identified as an IRAK binding partner and is involved in Lysine-63 polyubiquitination of IRAK 1/4 and RIP1, which are key mediators of the TLR and IL-1R signalling pathways. As such, these pathways are implicated in responses to bacterial and viral infections and common respiratory viru...
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University of Sheffield
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557517 |