Studies on the inhibition of human Hypoxia Inducible Factor (HIF) hydroxylases
Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular responses to hypoxia in metazoans. The activity and stability of the HIF-a subunits are regulated by prolyl and asparaginyl hydroxylation. Human HIF-lα prolyl hydroxylation occurs at Pro402 and Pro564...
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University of Oxford
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558435 |