Synthesis of gemcitabine and it's tetrafluorinated analogues
A novel synthesis of the 2-deoxy-2,2-difluorocytidine nucleoside analogue gemcitabine has been achieved. Starting from the known 3,5-O-dibenzoyl-2- deoxy-2,2-difluororibose, the nucleobase moiety is constructed in a linear fashion, using amino- or urea glycosylation methodology. This methodology has...
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University of Southampton
2011
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561554 |